Induction of Immunological Tolerance by Oral Anti-CD3

Induction of Immunological Tolerance by Oral Anti-CD3

In recent years, our knowledge about immunoregulation and autoimmunity has significantly advanced, but nontoxic and more effective treatments for different inflammatory and autoimmune diseases are still lacking. Oral tolerance is of unique immunologic importance because it is a continuous natural immunologic event driven by exogenous antigen and is an attractive approach for treatment of these ...

Monoclonal Antibodies: Evidence for an IL-4 Tolerance Induction by Anti-CD2 Plus Anti-CD3

Tolerance induction by anti-CD2 plus anti-CD3 monoclonal antibodies: evidence for an IL-4 requirement.

Anti-CD2 mAb plus anti-CD3 mAb induce alloantigen specific tolerance. We sought to determine whether Th2 cytokines are involved in the induction of tolerance in this model. Addition of anti-IL-4 mAb or anti-IL-10 mAb to anti-CD2 plus anti-CD3 treatment abrogated tolerance and resulted in graft survivals of 26+/-4 and 25+/-5 days, respectively. Splenocytes from the anti-IL-4 mAb and anti-IL-10 g...

Immunological Tolerance: Therapeutic Induction

Immunological tolerance can be defined as an unresponsiveness of T and/or B cells to self antigens. Low responsiveness of T cells and/or B cells to self antigens could be termed partial tolerance. Protection from the development of autoimmune diseases and acceptance of transplanted organs or tissue are due to effective tolerance to self antigens and alloantigens, respectively. The breakdown of ...

Immunological changes related to oral tolerance

Background The default response to protein antigens in the intestine is the induction of systemic and local hyporesponsiveness (OT). There is increasing interest in the role of dietary manipulation and probiotics in the development and prevention of allergic and other diseases. Little is known how the environment and nutritional factors modulate systemic and local immune responses. This present...